| 期刊詳細資料 Journal detailed information |
| 作者(Author) | Shang-Ying Shiu, Constantine Gatsonis |
| 篇名(Article title) | On ROC analysis with nonbinary reference standard |
| 期刊名(Journal name) | Biometrical Journal |
| 國際期刊(International Journal) | SCI |
| 中文摘要(Abstrct) | |
| ABSTRCT | Statistical methods for the evaluation of the accuracy of diagnostic tests usually assume a binary true
disease status. However, this assumption may not be realistic in practical settings in which “disease” is
defined by dichotomizing continuous or ordinal categorical measures using a pre-specified threshold
value. In this paper,we focus on the analysis of studies inwhich both the diagnostic test and the reference
standard are reported as continuous measures. We propose a semiparametric model for estimating the
sensitivity, specificity, and the ROC curve as functions of reference standard thresholds. Under suitable
order restrictions on the mean of the test result variable, fitting is done via two alternative approaches:
isotonic regression and monotone smoothing splines. The model provides the basis to assess the effect of
varying reference standard threshold on the performance of a diagnostic test. An example to evaluate
the ability of the maximal SUV-lean (standardized uptake value normalized to lean body mass) in
predicting axillary node involvement in women diagnosed with breast cancer is presented. |
| 中文關鍵字(Keyword) | |
| KEYWORD | Diagnostic test; Reference standard; ROC analysis |
| 卷期(Volume No) | Vol. 54 No. 4 |
| 頁數(Page number) | pp. 457~480 |
| 年份(Year) | 2012 |
| 語言(Language) | 英文 English |